stacy hung
Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study
Our work on the Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study has been published in PLoS Medicine! This work was co-led by Robert Kridel and Fong Chun Chan and illuminates the contrasting modes of evolution shaping the clinical histories of transformation and progression with implications in the context of treatment-induced selective pressures.
Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell of origin-specific clinical impact
Our work on Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell of origin-specific clinical impact has been published in Blood! This work was led by Daisuke Ennishi and demonstrates that cell-of-origin subtype-specific biomarkers based on BCL2 genetic alterations can be used to risk stratify DLBCL patients treated with immunochemotherapy.
Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression
Our work on Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression has been published in Cell Reports! This work was co-led by Anja Mottok and Bruce Woolcock and establishes that CIITA alterations are a common mechanism of immune escape.
Comprehensive characterization of programmed death ligand structural rearrangements in B-cell non-Hodgkin lymphomas
Our work on Comprehensive characterization of programmed death ligand structural rearrangements in B-cell non-Hodgkin lymphomas has been published in Blood! This work was led by Lauren Chong and reveals that PDL structural rearrangements cluster in discrete breakpoint regions, and are significantly associated with increased protein expression while limiting T-cell activation.