News

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Our work demonstrates for the first time, a clinical and biological role of TMEM30A in human cancer.  The study, which was led by Daisuke Ennishi and Shannon Healy, uncovers clinically relevant mutations in DLBCL patients, and through the use of knockout mouse models and drug assays provide new biological insights into membrane physiology in B-cell […]

Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

Our work establishes for the first time the phenotype of the Hodgkin lymphoma-specific immune microenvironment at single-cell resolution.  The study, which was led by Tomohiro Aoki and Lauren Chong, identifies a regulatory T-cell-like immunosuppressive subset of LAG3+ T cells contributing to the immune-escape phenotype and insights aiding in the development of novel biomarkers and combination […]

The Ride to Conquer Cancer 2019

The Ride to Conquer Cancer 2019

The Steidl Lab participated in the 2019 Ride to Conquer Cancer to help raise money for life-saving research at BC Cancer – support Team Blood, Sweat and Cures!

Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma

Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma

Our work on the mutational landscape of PMBCL has been published in Blood!  This work, which was led by Stacy Hung and Anja Mottok, highlights the IRF-pathway as a putative novel hallmark and the importance of JAK1, RELB and EP300 mutations in driving oncogenic signaling.

The Ride to Conquer Cancer 2018

The Ride to Conquer Cancer 2018

The Steidl Lab is participating in the 2018 Ride to Conquer Cancer to help raise money for life-saving research at BC Cancer! Support Team Blood, Sweat and Cures!