stacy hung
Mutational Landscape of Grey Zone Lymphoma
Using exome and targeted sequencing, our work uncovers for the first time, the mutational landscape of grey zone lymphoma (GZL). The study, which was led by Clementine Sarkozy, highlights distinct mutational profiles between thymic and non-thymic GZL, and the unique landscape of poly-EBV-L. These results suggest distinct cells-of-origin and modes of disease evolution within the […]
Gene expression profiling of gray zone lymphoma
Using gene expression profiling, our work provides a comprehensive phenotypic characterization of Grey Zone Lymphoma (GZL), highlighting the importance of tumor microenvironment biology and macrophage infiltration. The study, which was led by Clementine Sarkozy, confirms and further characterizes the existence of two groups of GZL with presumably distinct cells of origin and evolutionary modes, as […]
TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Our work demonstrates for the first time, a clinical and biological role of TMEM30A in human cancer. The study, which was led by Daisuke Ennishi and Shannon Healy, uncovers clinically relevant mutations in DLBCL patients, and through the use of knockout mouse models and drug assays provide new biological insights into membrane physiology in B-cell […]
Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma
Our work establishes for the first time the phenotype of the Hodgkin lymphoma-specific immune microenvironment at single-cell resolution. The study, which was led by Tomohiro Aoki and Lauren Chong, identifies a regulatory T-cell-like immunosuppressive subset of LAG3+ T cells contributing to the immune-escape phenotype and insights aiding in the development of novel biomarkers and combination […]
The Ride to Conquer Cancer 2019
The Steidl Lab participated in the 2019 Ride to Conquer Cancer to help raise money for life-saving research at BC Cancer – support Team Blood, Sweat and Cures!
Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma
Our work on the mutational landscape of PMBCL has been published in Blood! This work, which was led by Stacy Hung and Anja Mottok, highlights the IRF-pathway as a putative novel hallmark and the importance of JAK1, RELB and EP300 mutations in driving oncogenic signaling.
The Ride to Conquer Cancer 2018
The Steidl Lab is participating in the 2018 Ride to Conquer Cancer to help raise money for life-saving research at BC Cancer! Support Team Blood, Sweat and Cures!
Somatic IL4R Mutations in Primary Mediastinal Large B-cell lymphoma lead to constitutive JAK-STAT signaling activation
Our work on IL4R mutations in PMBCL has been published in the Blood! This work, which was led by Elena Viganò, establishes IL4R mutations as novel driver alterations and provides a strong preclinical rationale for therapeutic targeting of JAK-STAT signaling in PMBCL.
Assessment of Capture and Amplicon-Based Approaches for the Development of a Targeted Next-Generation Sequencing Pipeline to Personalize Lymphoma Management
Our work on a sequencing assay that allows for the screening of “actionable” gene mutations in lymphoid tumors has been published in the Journal of Molecular Diagnostics! This work, which was led by Stacy Hung, establishes the feasibility of capture sequencing on routinely acquired biopsy materials and demonstrates the clinical utility of integrating a lymphoma-specific pipeline […]
Prognostic Model to Predict Post-Autologous Stem-Cell Transplantation Outcomes in Classical Hodgkin Lymphoma
Our work on a novel gene expression-based prognostic model of post-autologous stem-cell transplanted (ASCT) failure-free survival in cHL has been published in Journal of Clinical Oncology! This work, which was co-led by Fong Chun Chan and Anja Mottok, has led to the development of a validated clinically applicable prognostic assay that at the time of first relapse […]