Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma

Our work on the mutational landscape of PMBCL has been published in Blood!  This work, which was led by Stacy Hung and Anja Mottok, highlights the IRF-pathway as a putative novel hallmark and the importance of JAK1, RELB and EP300 mutations in driving oncogenic signaling.